UK polynucleotide injection published price observations

2026-10-08 · Observation 1

On 8 October 2026 we read the same 24 UK provider websites across six cities and recorded every price they published for a polynucleotide treatment. Eleven published a price of some kind and seven published a single injected session price for the full face, which run from £200 to £500. Only one brand, Plinest, is named and priced for the full face by three separate providers, and those figures are £250, £275 and £300, a median of £275. The brand carries the price: one provider publishes Plinest at £275 and Vitaran at £220 for the same area on the same page. These are prices providers published, not quotations, and they do not establish what any treatment will cost you.

What this record is, and what it is not

This page exists because the cost of polynucleotides is quoted everywhere and sourced almost nowhere. A reader, a journalist or a resource page that wants to say what polynucleotides cost in the United Kingdom usually has to rely on a figure with no date, no sample and no way to check it. This record is the opposite of that: a fixed number of named provider pages, read on a stated date, with every figure traceable to the page it came from.

It is a record of published prices. It is not a price list, not a quotation, not an offer and not a comparison of providers. It does not rank anybody, recommend anybody or say that one appointment is better value than another. A price cannot show which brand is used, how many vials, by whom, or whether polynucleotide injections are appropriate at all.

This treatment resists comparison in four ways at once, and all four had to be settled before a page was opened. It is sold under brand names that are not the same product: Plinest, Nucleofill, Vitaran, Plenhyage, PhilArt, Ameela and Juvelook all appear on UK price lists. It is priced by vial volume, and a 2ml syringe and a 4ml treatment are both sold as a full face. It is priced by area, with the under eye region usually listed separately from the face. And it is sold both as a single session and as a course of two to four. The unit here is therefore one injected session to the full face, at a named brand and at the volume the provider states, and brands are never pooled with one another.

Observation 1: 8 October 2026

The one figure that can honestly be pooled

Plinest is the only polynucleotide brand on this panel that three separate providers name and price for the full face: trueyouskinclinics.co.uk at £250 for a 2ml syringe, boonaesthetics.com at £275 for the full face, and dermoperfection.co.uk at £300 for a 2ml syringe. That is the pooled set, and it is a small one.

Every single session full face figure recorded

Nine figures from seven providers price a single injected session to the full face. They are listed rather than pooled, because four different brands and two different vial volumes are involved and the brand demonstrably carries the price.

The spread is £200 to £500. No median is given for it, because averaging four brands at two volumes would produce a number that no provider on this panel publishes.

The brand carries the price, on the same page

boonaesthetics.com publishes five polynucleotide brands in one table, each for the same areas. For the full face, Plinest is £275 and Vitaran is £220: a difference of 25 per cent between two products a reader would see described in the same words on the same page. Plenhyage XL sits between them at £270. The same page also lists a generic polynucleotide under eye treatment and a 2ml polynucleotide skin booster, both at £275, which is its Plinest full face price.

This repeats the finding of this directory’s Morpheus8 record, where one provider published a branded line 36 per cent above the generic line for the same modality on the same page. On this panel the brand premium is smaller but it is published openly, side by side, rather than hidden across two pages.

Volume, not area, is what actually moves the price

The clearest observation on this panel is a single provider publishing the same brand at two volumes. dermoperfection.co.uk lists a Plinest 2ml syringe at £300 and a full face 4ml treatment at £500. Twice the product costs 67 per cent more, and both are sold for the face. A reader comparing two clinics on the word polynucleotides alone, with no volume stated, is often comparing two different amounts of product. Only two providers on this panel state a volume at all.

The under eye area is not priced above the face

Polynucleotides are widely described as costing more around the eyes. On this panel they are not. Four providers publish both an under eye and a face price for the same product, and none of them prices the under eye area higher.

leeds-clinic.co.uk goes further and publishes one price, £200, for eyes, face and hair alike, so area makes no difference to the price at all there.

Course pricing, published rather than derived

This is the clearest difference between this record and the Morpheus8 record on this directory, where a course price had to be derived because almost nobody published one. Here six providers publish a course of three to the face outright, and every one of them is below three times the single session price.

Courses of three run from £550 to £800. Taking Plinest alone, the only brand-consistent set, three providers publish a course of three at £695, £701.25 and £800, a median of £701.25. Because most providers recommend a course of two to four sessions, the course figure is closer than the single session figure to what a reader is actually buying.

Two providers publish a course of four as well: dermoperfection.co.uk at £1,600 for a 4ml full face course and £995 for a 2ml course. One publishes a course of six: edenskinclinic.co.uk at £1,100 for full face and neck, by microneedling rather than injection.

Prices that exist but cannot be used

Four providers publish a figure that looks like a polynucleotide price and is not usable as one. Each is listed in the register with the reason.

• monacomedical.co.uk prices two different products on one line. Its table is headed Profhilo / Polynucleotides and gives one session at £400, two sessions at £750 and three at £900. Profhilo is a hyaluronic acid skin booster, not a polynucleotide. The figure cannot be attributed to either product, so none of it enters the record.
• edenskinclinic.co.uk delivers polynucleotides by microneedling, not by injection. Its PDRN Skin Rejuvenation is £375 for a single full face session and £425 for face and neck. That is a different route into the skin and a different treatment, so it is recorded and kept out of the figures.
• clnq.com publishes a starting figure with no area. It states the cost is from £300 a session and that the price depends on the number of syringes, the sessions booked and the doctor. A from price with no area and no volume cannot be pooled with a stated one.
• skinozaclinic.co.uk prices hair only. It publishes £240 a session and £600 for three for polynucleotide hair treatment, and no face price, so it sits outside the face figures.

Method

The method is written out here so that the figures can be checked and the observation repeated.

When. All 24 pages were read on 8 October 2026, and the four pages that refuse automated reading were re-tested on the same date to confirm they still do.

Who. The same fixed panel of 24 UK provider websites this directory uses for every price record, across London, Manchester, Birmingham, Leeds, Glasgow and Edinburgh. The panel is not changed between treatments, so the records can be compared with one another. A page is included when it is a provider’s own website publishing prices for its own treatments.

What counts as a figure. A price published in text, in pounds sterling, against a polynucleotide product. For an injectable the provider’s own treatment page was opened first, because the main price list often omits it. Prices published only as an image or inside a PDF were not read, and that is recorded rather than worked around.

What was fixed before reading. The unit, one injected session to the full face at a named brand and stated volume, was chosen before any page was opened, on the evidence of the Morpheus8 observation that a brand name carries a price. Brands are recorded and never pooled. A provider that names no brand is recorded as naming none rather than assumed to use any particular one.

What was excluded and why. Microneedled delivery of polynucleotides, because it is a different route. Prices shared on one line with a different product, because they cannot be attributed. Starting figures with no area or volume. Hair and lip only prices, which are listed but kept out of the face figures. Sunekos, Profhilo and other skin boosters that are not polynucleotides, even where a provider groups them under the same heading.

What this is not. Not a survey of the market, not a sample designed to be representative, and not advice. Twenty four providers in six cities is a panel, not a population. Prices change without notice and should be checked with the provider directly before booking.

Sources observed

All 24 pages read on 8 October 2026, with what each published. Addresses are given as text so the record can be checked.

Version history

This record is republished rather than edited. Each observation keeps its own date and figures, so a citation stays accurate after the next observation is made.

• Observation 1, 8 October 2026. 24 provider pages across six cities, 11 publishing a polynucleotide price of some kind, 51 figures recorded against a named brand, volume or area, 7 publishing a single injected session price for the full face from £200 to £500, and 3 publishing one for Plinest to the full face: £250, £275 and £300, a median of £275. Three of the panel do not offer the treatment. Four offer it and publish no price.

Related reading on this directory: polynucleotides, every price record on this directory, the Morpheus8 price record, the HydraFacial price record, the anti-wrinkle injection price record, the dermal filler price record, the skin peel price record, the laser hair removal price record, the thread lift price record, how we verify and our editorial policy.